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HIV - AIDS Forschung  /  HIV - AIDS Research

Die HIV-Forschung ist stark klinisch orientiert. Sie fußt zu einem guten Teil auf der großen Zahl der über die Jahre systematisch gesammelten Proben (Seren, Plasmen, Biopsien). Daraus ergaben und ergeben sich wichtige horizontale wie auch longitudinale Analysen.

HIV-related research activities represent mainly clinical research. These investigations build on a large number of patient samples (sera, plasma, PBMCs, biopsies), that have been collected over many years in a systematic fashion. This enables important horizontal as well as longitudinal analyses, many of them as part of large European cohort studies.

 

Epidemiologie der HIV Infektion in Österreich 2017 / Epidemiology of HIV infection in Austria 2017

 

Ausgewählte Publikationen

Wang Q, De Luca A, Smith C, Zangerle R, Sambatakou H, Bonnet F, Smit C, Schommers P, Thornton A, Berenguer J, Peters L, Spagnuolo V, Ammassari A, Antinori A, Roldan EQ, Mussini C, Miro JM, Konopnicki D, Fehr J, Campbell MA, Termote M, Bucher HC; Hepatitis Coinfection and Non Hodgkin Lymphoma project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. 2017. Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients: A Cohort Study. Ann Intern Med. 166:9-17.

 

Bouteloup V, Sabin C, Mocroft A, Gras L, Pantazis N, Le Moing V, d'Arminio Monforte A, Mary-Krause M, Roca B, Miro JM, Battegay M, Brockmeyer N, Berenguer J, Morlat P, Obel N, De Wit S, Fätkenheuer G, Zangerle R, Ghosn J, Pérez-Hoyos S, Campbell M, Prins M, Chêne G, Meyer L, Dorrucci M, Torti C, Thiébaut R; Standard Reference Distribution of CD4 Response to HAART Project Team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. 2017. Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients. HIV Med. 18:33-44.

 

Leierer G, Grabmeier-Pfistershammer K, Steuer A, Sarcletti M, Geit M, Haas B, Taylor N, Kanatschnig M, Rappold M, Ledergerber B, Zangerle R. 2016. A Single Quantifiable Viral Load Is Predictive of Virological Failure in Human Immunodeficiency Virus (HIV)-Infected Patients on Combination Antiretroviral Therapy: The Austrian HIV Cohort Study. Open Forum Infect Dis. 3(2):ofw089.

 

Olson AD, Guiguet M, Zangerle R, Gill J, Perez-Hoyos S, Lodi S, Ghosn J, Dorrucci M, Johnson A, Sannes M, Moreno S, Porter K; for CASCADE Collaboration in EuroCoord. 2014. Evaluation of Rapid Progressors in HIV Infection as an Extreme Phenotype. J Acquir Immune Defic Syndr. [Epub ahead of print]

 

Engsig FN, Zangerle R, Katsarou O, Dabis F, Reiss P, Gill J, Porter K, Sabin C, Riordan A, Fätkenheuer G, Gutiérrez F, Raffi F, Kirk O, Mary-Krause M, Stephan C, de Olalla PG, Guest J, Samji H, Castagna A, d'Arminio Monforte A, Skaletz-Rorowski A, Ramos J, Lapadula G, Mussini C, Force L, Meyer L, Lampe F, Boufassa F, Bucher HC, De Wit S, Burkholder GA, Teira R, Justice AC, Sterling TR, M Crane H, Gerstoft J, Grarup J, May M, Chêne G, Ingle SM, Sterne J, Obel N; Antiretroviral Therapy Cohort Collaboration (ART-CC) and the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. 2014. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery. Clin Infect Dis, 58:1312-21, 2014
 
Mocroft A, Lundgren JD, Sabin ML, Monforte Ad, Brockmeyer N, Casabona J, Castagna A, Costagliola D, Dabis F, De Wit S, Fätkenheuer G, Furrer H, Johnson AM, Lazanas MK, Leport C, Moreno S, Obel N, Post FA, Reekie J, Reiss P, Sabin C, Skaletz-Rorowski A, Suarez-Lozano I, Torti C, Warszawski J, Zangerle R, Fabre-Colin C, Kjaer J, Chene G, Grarup J, Kirk O; Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCoord. 2013. Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE). PLoS Med, 10(9):e1001510. doi: 10.1371/journal.pmed.1001510
 
Touloumi G, Pantazis N, Pillay D, Paraskevis D, Chaix ML, Bucher HC, Kücherer C, Zangerle R, Kran AM, Porter K; CASCADE collaboration in EuroCoord. 2013. Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts. Clin Infect Dis, 56:888-897. 2013

 

Zangerle R, Kurz K, Neurauter G, Kitchen M, Sarcletti M, Fuchs D. 2012. Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy. Brain Behav Immun, 24:403-8
 

Taylor N, Touzeau V, Geit M, Gisinger M, Egle A, Greil R, Rieger A, Zangerle R. 2011. Raltegravir in pregnancy: a case series presentation. Int J STD AIDS 22:358-60

 

Kurz K, Teerlink T, Sarcletti M, Weiss G, Zangerle R, Fuchs D. 2009. Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers. Pharmacol Res, 60:508-14

 
Schroecksnadel K, Winkler C, Werner ER, Sarcletti M, Romani N, Ebner S, Schennach H, Fuchs D, Zangerle R. 2009. Interferon-gamma-mediated pathways and in vitro PBMC proliferation in HIV-infected patients. Biol Chem, 390:115-123, 2009

Schroecksnadel K, Winkler C, Sarcletti M, Romani N, Banki Z, Ebner S, Fuchs D, Zangerle R. 2009. Parameters of soluble immune activation in vivo correlate with the proliferative capacity of peripheral blood mononuclear cells in vitro in HIV-infected patients. J AIDS, 50:354-359
 
 
 

 

Publikationen 1980 bis heute

 

INFORMATION UND KONTAKT  /  INFORMATION AND CONTACT

Univ.-Prof. Dr. med. Robert Zangerle
e-Mail: robert.zangerle@tirol-kliniken.at

Bibliography

Universitätsklinik für Dermatologie und Venerologie | Anichstrasse 35, A-6020 Innsbruck | Tel.: (+43-512) 504-22971, Fax: (+43-512) 504-22990